Mocheso oa Polokelo ea Ente ea COVID-19: Hobaneng ULT Freezer?

Ka la 8 Tšitoe, United Kingdom e bile naha ea pele lefatšeng ho qala ho enta baahi ka ente e amohetsoeng ka botlalo ea Pfizer le e netefalitsoeng ea COVID-19.Ka la 10 Tšitoe, Tsamaiso ea Lijo le Lithethefatsi (FDA) e tla kopana ho buisana ka tumello ea tšohanyetso ea ente e tšoanang.Haufinyane, linaha lefatšeng ka bophara li tla be li latela mohlala ona, li nka mehato e nepahetseng ea ho isa limilione tsa linkho tsena tse nyenyane tsa khalase sechabeng ka mokhoa o sireletsehileng.

Ho boloka lithempereichara tse hlokahalang tse ka tlase ho zero tse hlokehang ho boloka bots'epehi ba ente e tla ba sesebelisoa se seholo bakeng sa baphatlalatsi ba ente.Joale, hang ha liente tseo e leng khale li letetsoe li qetella li fihlile likhemisi le lipetlele, li tlameha ho tsoela pele ho bolokoa mochesong o tlase ho zero.

Hobaneng ha Liente tsa COVID-19 li Hloka Lithempereichara tse tlase haholo?

Ho fapana le ente ea ntaramane, e hlokang ho bolokoa ka likhato tse 5 tsa Celsius, ente ea Pfizer's COVID-19 e hloka ho bolokoa ho -70 degrees Celsius.Mocheso ona o ka tlase ho zero o futhumala feela ka likhato tse 30 ho feta mocheso o batang ka ho fetesisa o tlalehiloeng Antarctica.Leha e sa bate haholo, ente ea Moderna e ntse e hloka mocheso o ka tlase ho -20 degrees Celsius, e le ho boloka matla a eona.

Ho utloisisa ka botlalo tlhoko ea lithempereichara tse batang, ha re hlahlobeng likarolo tsa ente le hore na liente tsena tse ncha li sebetsa joang.

mRNA Theknoloji

Meento e tloaelehileng, joalo ka ntaramane ea selemo, ho fihlela joale e sebelisitse kokoana-hloko e fokolang kapa e sa sebetseng ho susumetsa karabelo ea 'mele ea ho itšireletsa mafung.Liente tsa COVID-19 tse hlahisoang ke Pfizer le Moderna li sebelisa messenger RNA, kapa mRNA ka bokhutšoanyane.mRNA e fetola lisele tsa motho lifeme, e li nolofalletsa ho theha protheine e khethehileng ea coronavirus.Protheine e hlahisa karabelo ea 'mele ea ho itšireletsa mafung, joalo ka ha eka ho na le ts'oaetso ea 'nete ea coronavirus.Nakong e tlang, haeba motho a pepesehetse coronavirus, sesole sa 'mele se ka e loantša habonolo.

Theknoloji ea ente ea mRNA e ncha haholo 'me ente ea COVID-19 e tla ba ea pele ea mofuta oa eona ho amoheloa ke FDA.

The Fragility ea mRNA

Molek'hule ea mRNA e senyeha habonolo ka tsela e ikhethang.Ha e nke nako e ngata ho etsa hore e qhalane.Ho pepesehela mocheso o sa tsitsang kapa li-enzyme ho ka senya molek'hule.Ho sireletsa ente ho tsoa ho li-enzyme 'meleng ea rona, Pfizer e phuthetse mRNA ka lipompong tse mafura tse entsoeng ka lipid nanoparticles.Leha e na le bubble e sirelletsang, mRNA e ntse e ka senyeha kapele.Ho boloka ente lithempereichareng tse ka tlase ho zero ho thibela ho senyeha hona, ho boloka botšepehi ba ente.

Mekhoa e meraro ea Bobolokelo ba Ente ea COVID-19

Ho latela Pfizer, barekisi ba ente ba na le likhetho tse tharo ha ho tluoa tabeng ea ho boloka liente tsa bona tsa COVID-19.Bahlahisi ba ka sebelisa lihatsetsi tsa ULT, ba sebelisa likepe tse futhumetseng bakeng sa polokelo ea nakoana ho fihlela matsatsi a 30 (ba tlameha ho tlatsa leqhoa ka matsatsi a mang le a mang a mahlano), kapa ba boloke ka sehatsetsing sa ente ka matsatsi a mahlano.Moetsi oa meriana o tsamaisitse likepe tse futhumetseng tse sebelisang leqhoa le omileng le li-sensor tsa mocheso tse sebelisoang ke GPS ho qoba maeto a mocheso ha a ntse a le tseleng e eang moo a ka sebelisoang (POU).